Varun Sandesh

In 2007, Sandesh applied for auditions for a Sekhar Kammula film through an online advertisement, despite having no prior acting experience and previously planning to pursue medical studies.

He received a reply of one scene's film script, which he was asked to act out and send back. He shot and sent video clippings of himself to Kammula, which promptly landed him a lead role in the film Happy Days. Featuring an ensemble cast, comprised almost entirely with newcomers, Happy Days was a major critical and commercial success, winning several accolades, including six Filmfare Awards South and three Nandi Awards.

He then starred in romantic drama Kotha Bangaru Lokam (2008), which received critical acclaim and went on to become one of the biggest blockbusters of the year. Sandesh followed this initial success by starring in a number of films that did not perform well at the box office, including action film Kurradu (2009), a remake of the 2007 Tamil hit film Polladhavan, and romantic drama Maro Charitra (2010), a remake of the K. Balachander-directed 1978 blockbuster of the same title, which starred Kamal Haasan. Sandesh's career prospects declined further following a series of box office flops through the 2010s, with his only successes being the romantic comedy Yemaindi Ee Vela (2010), crime comedy D for Dopidi (2013), and ensemble comedy Pandavulu Pandavulu Thummeda (2014).

In 2019, Sandesh became a notable television personality for his participation in Star Maa's reality TV show Bigg Boss Telugu 3, reaching the grand finale and finishing in 4th place. Sandesh is also the brand ambassador for the Kalanjali store in Andhra Pradesh, India.