Santino Rice

Santino Rice attended classes at the Fashion Institute of Design and Merchandising in Los Angeles. Rice worked under Pegah Anvarian and Tony Duquette, prior to his involvement with the television series Project Runway.In 2005, Santino participated as a contestant on the second season of the Bravo reality show Project Runway, producing mixed results on the show. He won two challenges and was among the top three designs three more times. However, Rice was among the bottom two scores for four challenges. Ultimately, he lasted throughout the season and was one of three finalists selected to show at Olympus Fashion Week in New York City. He finished in third place, behind Daniel Vosovic and Chloe Dao.

Rice became known for the abrasive persona that he presented on Project Runway, and he was often cited as the "villain" of the show.

After Project Runway, Rice was selected to be one of the judges of the Miss Universe 2006 pageant. He was also asked by MTV VJ SuChin Pak to design her dress for the 2006 MTV Movie Awards. The following year, Rice made a guest appearance in the sixth episode of America's Most Smartest Model, in which he taught the contestants about fashion design. As of 2008, he was creating a new cigarette pack design for Camel, dressing a handful of elite private clients, and working on building his own clothing company.

More recently, Rice has been cast in two main roles in reality television. From 2009 to 2014, he was a judge on the Logo reality program RuPaul's Drag Race. Rice also starred in the Lifetime show On the Road with Austin and Santino, alongside fellow Project Runway alumnus Austin Scarlett. The show premiered in 2010, following Rice and Scarlett as they visited various American small towns, designing clothing for women who have upcoming special occasions. Rice also played a minor role as a homeless man in the 2010 independent queer cinema thriller L.A. Zombie.

In 2017, Rice appeared on an episode of The Doctors to talk about his controversial diet, the "111 Day Fast".