Samantha Mathis

Mathis was born in Williamsburg, Brooklyn, New York City, the daughter of Donald Mathis and Austrian-born actress Bibi Besch. Her parents divorced when she was two years old, and Mathis was brought up by her mother. She relocated with her mother to Los Angeles, California, at the age of five.

Besch tried to discourage Mathis from pursuing acting, but growing up on locations, in theaters, and in acting classes, Mathis knew she wanted to act. She decided to become an actress at the age of twelve.Mathis began acting professionally at the age of 16. Her first job was a commercial for "Always Slender Pads – Just for Teens". She co-starred in the television series Aaron's Way and Knightwatch from 1988 to 1989. Her first starring role in a feature film was that of Nora in Pump Up the Volume (1990), opposite Christian Slater, whom she briefly dated at the time. Mathis dyed her natural blonde hair black for the role in an effort to change her image from sweet and innocent to strong-willed.

Mathis appeared in the television films Extreme Close-up, 83 Hours 'til Dawn and To My Daughter in 1990. Mathis and Slater had voice roles in the animated film FernGully: The Last Rainforest (1992). She next appeared in the comedy This Is My Life (1992), written and directed by Nora Ephron, playing an insecure teenager. Mathis appeared in the play Fortinbras in New York City in October 1992. Super Mario Bros. (1993), in which she played Princess Daisy from the popular Nintendo video game, was a box-office bomb but gained a cult following since its release.

Mathis co-starred with River Phoenix in The Thing Called Love (1993). She appeared in the 1994 film adaptation of Little Women, and in How to Make an American Quilt (1995), both starring Winona Ryder. She then appeared in The American President (1995), playing the assistant to the President of the United States. Mathis costarred with Christian Slater again, along with John Travolta, in John Woo's Broken Arrow (1996). She took a little over a year off from acting after her mother died in 1996 from breast cancer.

Mathis later appeared in American Psycho (2000), a film adaptation of Bret Easton Ellis's 1991 novel of the same name. She starred in Attraction (2000) and in The Simian Line (2001). She starred in the TNT television miniseries The Mists of Avalon (2001). Mathis starred with Thomas Jane in The Punisher (2004). She had a guest role on the ABC television show Lost as Olivia Goodspeed. She played Jane Fonda's daughter in the Broadway show "33 Variations". Her indie film Lebanon, PA (2010) had its world premiere at the 2010 SXSW Film Festival. She appeared in an off-Broadway production of the play, Love, Loss, and What I Wore, at New York City's Westside Theatre in October 2011.

In 2013, Mathis played psychiatrist Alice Calvert on the CBS television series Under the Dome, based on a novel by Stephen King. In 2014, she joined the cast of the FX horror drama series The Strain as Justine Feraldo, a New York City councilwoman for Staten Island.

In October 2015, Mathis was elected National Vice President, Actors/Performers of SAG-AFTRA. She was re-elected in 2017.

In 2019, she appeared Off-Broadway in the role of Kate Conlee in Make Believe, a new play by Bess Wohl staged at the Second Stage Theater. Michael Greif directed.

Her 2020 musical Whisper House was postponed due to the COVID-19 pandemic.