Roxanne Guinoo

In 2004, Guinoo joined the popular reality TV show Star Circle Teen Quest aired on ABS-CBN and made it into the group of finalists known as the "Magic Circle of 5", along with co-stars Hero Angeles, Sandara Park, Joross Gamboa, and Melissa Ricks. In June 2004, the televised live final was held in Araneta Coliseum, where she finished in second place. She was introduced as one of the newest members of ABS-CBN's Star Magic. She made her ABS-CBN debut in the youth oriented drama SCQ Reload, with her SCQ co-finalists. She gained more acting roles from there, appearing in the romance show Love Spell while also co-hosting Wowowee for a while.

Her big break came when she was cast in a leading role in the 2007 drama series Sineserye Presents: Natutulog Ba ang Diyos?, with local television stars Dina Bonnevie and Rosanna Roces while also appearing with Gamboa and Jake Cuenca. Initially starting at 6:30 pm, it was moved to ABS-CBN's 9:30 primetime slot due to its popularity. She closed out the year by starring in Shake, Rattle and Roll 9, which was shown during that year's Metro Manila Film Festival.

In 2008, she took up her first solo lead role on ABS-CBN with a show entitled Ligaw na Bulaklak which aired in an afternoon slot. She also returned for Shake, Rattle & Roll X that year. It was also during that time that she joined Banana Split, where she got to show her comedy skills. Another comedy series she joined that year was in Everybody Hapi over TV5 (replacing ABC 5) as "Jenny", alongside John Estrada, Eugene Domingo, Long Mejia, Alex Gonzaga and Matt Evans. This marked her first project with the Kapatid Network.

In 2009, Guinoo starred in the superhero television show Komiks Presents: Flash Bomba with Luis Manzano. She also starred in the horror thriller series Florinda. However, she started getting less projects from the network. She used the time not spent for showbiz for her college studies.

She returned to showbiz with TV5 in 2012 and appeared in Valiente and an episode in Real Confessions before moving to GMA Network same year. The following year, she made her main character debuts in Home Sweet Home and Pyra: Ang Babaeng Apoy.

In 2015, she returned to do the TV series Walang Iwanan on her home network ABS-CBN. In 2021, she had her most successful project to date, Hoy, Love You!, a iWant TFC series that saw her reunite with Gamboa. The series lasted for three seasons. That year, she also made a special appearance in The General's Daughter.

As of 2023, she is semi-active in showbiz, occasionally doing TV shows but focusing more on her family life. In 2024, she was cast in the upcoming ABS-CBN drama series Lavender Fields.