Natasha Wightman

In 1999, Wightman starred in the British films The Feather Room and Romeo Thinks Again, with the latter production featuring Wightman as Juliet. In 2001, Wightman co-starred in the mystery film Gosford Park directed by Robert Altman. She portrayed Lady Lavinia, the sister of Kristin Scott Thomas's character and the wife of Lt. Commander Anthony Meredith (played by Tom Hollander). That year, Wightman also appeared in Revelation alongside James D'Arcy and Terence Stamp. Directed and written by Stuart Urban, the British adventure film features a team searching for an ancient relic once possessed by the Knights Templar. Wightman plays Mira, an alchemist.

In 2003, Wightman acted in several episodes of the British TV serial State of Play. The 2005 British film Mouth to Mouth, directed by Alison Murray, includes Wightman as Rose, the incompetent mother of the protagonist Sherry (played by Elliot Page).

The following year, Wightman appeared in the dystopian political thriller V for Vendetta as Valerie Page. Her character a lesbian who is imprisoned by the totalitarian regime due to her sexual orientation. The actress stated that during Valerie's incarceration, "She finds something, her integrity, which they can't take from her. She'd almost died and then come alive again through what she found in herself." Wightman shaved her head for the role, and felt this decision helped display prejudice faced by many lesbians. During this period, Wightman's neighbour called the police after assuming the actress was a man trying to break into her house. Slant Magazine praised Wightman's performance and voiceover work in the film, believing she "greatly helped" turn the prison scenes "into something poetic".