Lyke Mike

When Towers began his career, he initially posted his songs to SoundCloud, which gained popularity in Puerto Rico. Originally, his stage name was "Mike", but was later stylized to "Myke", joining the letters "Y" and "K", short for the moniker "Young Kingz". His mixtape El Final del Principio (2016) peaked at 12 on Latin Rhythm Albums. The mixtape was produced by the record label G Starr Entertainment and featured singles such as "Dinero en mano", "Déjate ver", "No sabe nada" and "Alternativas".

Towers collaborated with Bad Bunny with the song "Estamos Arriba" released in June 2019. On July 5, 2019, Piso 21 released the single "Una Vida Para Recordar" featuring Towers. He collaborated with Becky G with the song "Dollar"; a music video was released July 12, 2019. His first studio album Easy Money Baby was released on January 23, 2020, just one week after the birth of his son. The album peaked at number one on the Top Latin Albums chart for 83 consecutive weeks and was nominated for Best Urban Music Album at the Latin Grammy Awards. His EP Para Mi Ex was released on December 16, 2020.

His second album, Lyke Mike, was released on April 23, 2021. The title refers to his previous stage name, while the number of tracks (23) pays homage to the jersey number of former basketball player Michael Jordan. It features collaborations with Jon Z, Ñengo Flow, and Sahir.

His third studio album, La Vida Es Una was released on March 23, 2023. This album also had 23 songs, which included features from Arcángel, J Balvin, Chita, Ozuna, and Daddy Yankee. In July 2023, the song "Lala" topped charts in several countries after the use of the song went viral on TikTok. It also became Towers' first song to top Billboard's Global 200 US chart. In that same month, Towers signed a managerial deal with Brandon Silverstein’s S10 Entertainment.

Towers' fourth album, LVEU: Viva la Tuya… No la Mía, was released on November 23, 2023.

His fifth album, La Pantera Negra, was released on August 23, 2024. The album features collaborations with Peso Pluma, Jay Wheeler, Omar Montes, Cosculluela, and Yovngchimi.