Jordana Spiro

Spiro was born and raised in New York City. She is Jewish. Spiro has a brother and three sisters. She studied at the Circle in the Square Theatre School and briefly attended the Royal Academy of Dramatic Art in London. In fall 2009, she began the MFA Program in Filmmaking at Columbia University. She finished the degree in 2015. Spiro currently splits her time between Los Angeles and New York.Spiro's first film role was as Catherine Reece in the 1999 film, From Dusk Till Dawn 3: The Hangman's Daughter, a direct-to-DVD prequel to the 1996 film From Dusk till Dawn.

In 2000 Spiro starred in her first TV series, the USA crime drama The Huntress. Co-star Annette O'Toole and Spiro played mother and daughter bounty hunters, based on the lives of Dottie And Brandi Thorson. The series ran for 28 episodes, concluding in 2001.

Spiro starred in the TBS original comedy series My Boys. She played the role of P.J., a twenty-something "guy's girl", and sports reporter who tries to find romance within her world that is dominated by male friends. The series wrapped its fourth and final season on TBS in 2010.

Spiro also appeared in the 2009 comedy The Goods: Live Hard, Sell Hard alongside Jeremy Piven, Ed Helms and Rob Riggle, and produced by Will Ferrell and Adam McKay. The Goods was directed by Neal Brennan.

Additional credits include The Year of Getting to Know Us, which premiered at the 2008 Sundance film festival, IFC's Alone with Her, as well as guest appearances on Cold Case, Out of Practice, and CSI: NY.

Spiro was scheduled to star in the planned 2010–11 television series Love Bites, but fell out of the role in June 2010 due to other contractual obligations. Spiro was also cast alongside Nicolas Cage and Nicole Kidman in the thriller, Trespass. She was a guest star on the Showtime 2011 season of Dexter. For the 2012–13 season, she had the lead role in the Fox-TV medical/crime drama The Mob Doctor.

Recently, Spiro starred as Rachel Garrison in the Netflix crime drama Ozark.

In February 2024, Spiro joined the cast of Law & Order: Special Victims Unit as Shannah Sykes, an FBI agent on loan to the show's special victims unit squad.