Carla Gugino

Gugino was born on August 29, 1971 in Sarasota, Florida, to Carl Gugino, an orthodontist of Italian descent, and Susan Gugino, of English and Irish descent described as "Bohemian". After her parents separated when she was two, she travelled between the Sarasota home of her father and half-brother Carl Jr.'s, and the Paradise, California home of her mother.

She has said of her upbringing, "I lived in a tepee in northern California and a van in Big Sur. With my dad, I lived in a beautiful house with a swimming pool and a tennis court and went to Europe for the summers. So I feel like I lived two childhoods." She worked as a teenage fashion model, and took acting classes at the suggestion of her aunt, former Let's Make a Deal spokesmodel Carol Merrill. She eventually came to support herself, and with her parents' support, was legally emancipated by the time she was 16.Gugino's television work during the late 1980s and early 1990s included appearances on Good Morning, Miss Bliss, Saved by the Bell, Who's the Boss?, ALF, Doogie Howser, M.D., The Wonder Years, Webster and a recurring role on Falcon Crest. In film, Gugino appeared in the Shelley Long film Troop Beverly Hills (1989), and she co-starred with Pauly Shore in the romantic comedy Son in Law (1993). She appeared in the video to Bon Jovi's 1994 song "Always".

In 1995, Gugino appeared as Nan St. George (later the Duchess of Trevenick) with Greg Wise and James Frain in the BBC miniseries The Buccaneers, an adaptation of Edith Wharton's last novel. She played Ashley Schaeffer, Michael J. Fox's character's love interest, during the first season of the sitcom Spin City in 1996. She played opposite Nicolas Cage in Brian De Palma's Snake Eyes, and in Judas Kiss, which she also co-produced. She appeared as Dr. Gina Simon during the final season of the television medical drama Chicago Hope (1999–2000).

In 2001, she appeared as family matriarch Ingrid Cortez in the first Spy Kids film (as well as the film's two sequels in 2002 and 2003). That same year she appeared as Jet Li's love interest in the martial arts action thriller The One.

She starred in two short-lived TV series: ABC's Elmore Leonard crime drama Karen Sisco in 2003, and CBS' science fiction series Threshold in 2005. That same year, Gugino appeared as Lucille in the feature film adaptation of Frank Miller's graphic novel Sin City. The following year, she appeared in the film Night at the Museum as Ben Stiller's love interest.

Gugino made her Broadway debut in the Roundabout Theatre Company production of Arthur Miller's play, After the Fall opposite Peter Krause. In late 2006, she appeared in an Off-Broadway production of Tennessee Williams' Suddenly Last Summer opposite Blythe Danner.

Gugino appeared as Amanda, Vincent Chase's agent, in a dozen episodes of the cable television series Entourage. Gugino appeared in the May 2007 issue of Allure. That same year she appeared in the action-horror film Rise: Blood Hunter and the feature film American Gangster. The following year, she played the female lead in the thriller Righteous Kill, opposite Robert De Niro and Al Pacino.

In 2009, Gugino starred as Abby in Eugene O'Neill's Desire Under the Elms at the Goodman Theater in Chicago, Illinois. Charles Isherwood of The New York Times praised Gugino's performance, saying, "Ms. Gugino displays a depth and range of expression that I cannot imagine any other actress achieving with such blazing honesty and wrenching truth. She is simply magnificent." During the first three months of 2009, three feature films premiered featuring Gugino: the thriller The Unborn, the film Watchmen, in which she played Sally Jupiter, and the adventure remake Race to Witch Mountain, in which she starred opposite Dwayne Johnson. That April, she received an Outer Critics Circle Award nomination for Outstanding Actress in a Play for her performance in Desire Under the Elms. Later, in November of that year, she played a pornographic actress in the comedy film Women in Trouble, which spawned a sequel in 2010, Elektra Luxx, titled after her character.

In 2011, Gugino appeared as Madame Vera Gorsky in Zack Snyder's action-fantasy film Sucker Punch alongside Abbie Cornish and Emily Browning. Gugino sang a duet with co-star Oscar Isaac, which appeared in the end credits and in the film's soundtrack. She also guest starred on the fourth season of Californication as Abby Rhodes, Hank Moody's attorney and love interest.

In 2012, Gugino had a lead role as Susan Berg, a Washington, D.C., investigative reporter, on the USA Network's miniseries Political Animals. In 2015, she had a lead role in the disaster film San Andreas, in which she once again starred opposite Dwayne Johnson.

In 2020, Gugino played Carol in Alice Birch's Anatomy of a Suicide at the Atlantic Theater Company.