Kali Reis

Reis was born in Providence, Rhode Island, on August 24, 1986, the youngest of five children. She and her siblings were raised by their mother in East Providence. She has Cape Verdean ancestry and identifies as being Afro-Indigenous, specifically of Wampanoag, Cherokee, and Nipmuc descent. She is a member of the Seaconke Wampanoag Tribe, an unrecognized tribe in Massachusetts.

As a child, she attended and competed in powwows regularly. She has incorporated the name Mequinonoag, which she translates as "many feathers" or "many talents" into her boxing nickname, "K.O. Mequinonoag. The name was given to her by her mother, whom Reis identifies as being "the medicine woman of our Seaconke Wampanoag tribe."

Reis was an athletic child and often played rougher sports with the neighborhood boys. She was involved in her junior high and her high school marching bands and color guards and competed in high school volleyball, basketball and softball. She started boxing at age 14 out of Manfredo's Gym in Pawtucket, Rhode Island, and was coached by a friend of her mother at her house.

Reis later attended school for criminology and also learned how to repair motorcycles at MTTI. She continued her training at Manfredos Gym and Big Six Boxing Academy in Providence.

Before going pro, Reis had a successful amateur career, securing the 2007 Rocky Marciano Championship, the 2007 NYC Golden Gloves, and the 2006 New England 154 Championship. While beginning her boxing career, she also worked in nightclub security. During this time, she sued the city after being attacked by a police officer.In 2012, Reis was involved in a serious motorcycle accident that sidelined her for the remainder of the boxing season. However, she returned in 2013 and fought for the WIBA title in November of that year. Reis gained further attention in the sport after the match. On November 12, 2014, Reis won the IBA crown defeating Teresa Perozzi in Bermuda. Reis also coaches boxing for youth and works as a trainer. In April 2016, Reis won her first major world title in New Zealand against Maricela Cornejo for the vacant WBC World Middleweight title.

HBO broadcast its first women's bout, between Cecilia Brækhus and Reis, on May 5, 2018, which Brækhus won.

Reis won a total of 19 fights during her career, 5 by knockout.

Reis became involved in Catch the Fair One after filmmaker Josef Kubota Wladyka discovered Reis's advocacy for the MMIWG movement and asked if she would collaborate as a co-writer and lead actress on a film about that subject. Catch the Fair One premiered in June 2021 at the Tribeca Film Festival. The film and Reis's debut performance received critical acclaim.

Reis was cast in Jean-Stéphane Sauvaire's 2023 film Asphalt City (originally titled Black Flies, adapted from the 2008 novel of the same name by Shannon Burke), starring Sean Penn, Tye Sheridan, and Katherine Waterston.

In June 2022, Reis was announced as the co-lead of True Detective: Night Country, the fourth season of HBO's anthology crime series. Reis starred alongside Jodie Foster as a detective investigating the disappearance of eight men from an Alaskan research station and that event's possible connection to the earlier murder of a young woman, an Iñupiaq activist.