Jodi Lyn O'Keefe

O'Keefe was born in the Cliffwood Beach section of Aberdeen Township, New Jersey.

She graduated from St. John Vianney High School.O'Keefe started her career as a model at the age of eight, and she modeled for a jeans company. Midway through her junior year of high school, O'Keefe left school to star on the soap opera Another World, playing Marguerite "Maggie" Cory. She then got a role on Nash Bridges playing Cassidy, the daughter of Don Johnson's title character. She and her mother moved to Hollywood so O'Keefe completed her schooling by mail.

Her film debut was in 1998, in Halloween H20: 20 Years Later and later starred in such films as The Crow: Salvation, Whatever It Takes and Devil in the Flesh 2. In 1999, she co-starred in the teen film She's All That (1999) as Taylor Vaughan alongside Freddie Prinze Jr. and Rachael Leigh Cook.

O'Keefe kept on filming both movies and Nash Bridges until the series ended in 2001. Later films have included Out for Blood, in which she played a vampire named Layla Simmons and Venice Underground. On the small screen, she has appeared in various shows including Dharma & Greg, Boston Legal, Two and a Half Men, Charmed, The Evidence, The Big Bang Theory, and Tru Calling.

In 2007, O'Keefe starred in the series Prison Break; in its third and fourth seasons. She said that she "truly loved" playing Gretchen Morgan, because it "challenged" her, and because Gretchen was the "polar opposite of her" and "was badass".

In 2014, O'Keefe was cast in a recurring role in VH1's TV series Hit the Floor, and appeared in the film Merry ExMas. That year, she had the recurring role of Jo in the sixth season of The CW series The Vampire Diaries. She reprised her role of Jo in the first season of Legacies.

In 2009, she appeared in the video game Command & Conquer: Red Alert 3 - Uprising.

On June 22, 2011, she started a clothing line, Queen George Clothing. In 2012, she launched a jewelry line, Q.